| Main Title |
Acute Behavioral Toxicity of Sulfolane: Influence of Hypothermia. |
| Author |
Ruppert, P. H. ;
Dyer, R. S. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1985 |
| Report Number |
EPA/600/J-85/278; |
| Stock Number |
PB86-159993 |
| Additional Subjects |
Solvents ;
Hypothermia ;
Toxicology ;
Oxygen consumption ;
Behavior ;
Rats ;
Laboratory animals ;
Reprints ;
Sulfolane
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-159993 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Sulfolane is a solvent which produces hypothermia and decreased oxygen consumption following acute exposure. In the present experiment, the author investigated effects of sulfolane on a behavioral measure of toxicity at ambient temperatures which would either prevent or facilitate the development of hypothermia. Adult, male Long Evans rats (N=10/dose) received a single i.p. injection of saline, 200, 400 or 800 mg/kg sulfolane. Motor activity in figure-eight mazes was assessed 1 hr after dosing in testing rooms maintained at either 20.8 C or at 32.3 C. At the warm ambient temperature, sulfolane produced hypoactivity but not hypothermia. At the cooler temperature, sulfolane-induced hypoactivity was more pronounced, and rats were hypothermic. Therefore, a behavioral change could be detected at sublethal dosages of sulfolane in the absence of hypothermia. |
| Supplementary Notes |
Pub. in Toxicology Letters 28, p111-116 Nov 85. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Acute Behavioral Toxicity of Sulfolane: Influence of Hypothermia. |
| PUB Date Free Form |
1985 |
| Category Codes |
6T; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
611415762 |
| Origin |
NTIS |
| Type |
CAT |
