| Main Title |
Effect of Ambient Temperature on the Hypometabolic and Hypothermic Effects of Sulfolane in Rats. |
| Author |
Gordon, C. J. ;
Long, M. D. ;
Dyer, R. S. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1984 |
| Report Number |
EPA/600/J-84/366; |
| Stock Number |
PB86-169885 |
| Additional Subjects |
Toxicology ;
Temperature ;
Hypothermia ;
Hypometabolism ;
Rats ;
Laboratory animals ;
Bioassay ;
Dosage ;
Reprints ;
Sulfolane
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-169885 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Sulfolane toxicity may be partially due to its effects on body temperature. To examine the effects of sulfolane on thermoregulation, the authors measured metabolic rate and body temperature in rats injected intraperitoneally with sulfolane at dosages of 0, 200, 400, and 800 mg/kg. At ambient temperatures (Ta) of 15 and 25 C sulfolane caused a dose related inhibition in metabolic rate and hypothermia 60 minutes post-injection. At a Ta of 35 C sulfolane had no effect on body temperature or metabolic rate. The hypometabolic and hypothermic effect of sulfolane at a Ta of 25 C lasted at least 2.5 hrs. Sulfolane had a similar effect on body temperature at Ta's of 15 and 25 C, hence, the sulfolane-treated rat had some control over body temperature with decreasing Ta. |
| Supplementary Notes |
Pub. in Archives of Toxicology 56, n2 p123-127 Dec 84. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effect of Ambient Temperature on the Hypometabolic and Hypothermic Effects of Sulfolane in Rats. |
| PUB Date Free Form |
1984 |
| Category Codes |
6T; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
612920161 |
| Origin |
NTIS |
| Type |
CAT |
