| Main Title |
Urethane Affects the Rat Visual System at Subanesthetic Doses. |
| Author |
Dyer, R. S. ;
Rigdon, G. C. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/251; |
| Stock Number |
PB88-177258 |
| Additional Subjects |
Anesthetics ;
Rats ;
Laboratory animals ;
Neurophysiology ;
Dosage ;
Reprints ;
Urethane
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-177258 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
Urethane is an anesthetic which is commonly used in neurophysiological studies because it is presumed to have minimal effects upon neuronal activity. The study investigated the influence of urethane anesthesia upon flash evoked potentials (FEPs) recorded from hooded rats. 1 subanesthetic dosages (.25 g/kg and .5 g/kg) and an anesthetic dosage (1.0 g/kg) were administered, and subsequently recorded FEPs were compared to vehicle-injected controls. Urethane produced profound qualitative and quantitative effects upon the FEP. At .5 g/kg, the P1 (normal latency = 20 msec) and N1 (normal latency = 30 msec) peaks became unrecognizable. Peak N1 disappeared and peak P1 merged with P2 (normal latency = 45 msec). Peak P2 increased in amplitude by about 100%. The results indicate that in the visual system, urethane has a significant influence upon neuronal activity. Caution should be used in interpreting data obtained from urethane-anesthetized rats. |
| Supplementary Notes |
Pub. in Physiology and Behavior, v41 p327-330 1987. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Urethane Affects the Rat Visual System at Subanesthetic Doses. |
| PUB Date Free Form |
1987 |
| Category Codes |
57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
812726859 |
| Origin |
NTIS |
| Type |
CAT |
