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Main Title Sulfolane Effects on Audiogenic, Pentylenetetrazol and Afterdischarge Seizure Activity.
Author Burdette, L. J. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
Publisher c1986
Year Published 1986
Report Number EPA/600/J-86/487;
Stock Number PB89-105399
Additional Subjects Convulsants ; Toxic substances ; Toxicity ; Seizures ; Hippocampus ; Laboratory animals ; Exposure ; Central nervous system ; Sulfur heterocyclic compounds ; Body temperature ; Pentylenetetrazol ; Drug synergism ; Nitrogen heterocyclic compounds ; Reprints ; Sulfolane ; Thiophene dioxide/tetrahydro
Library Call Number Additional Info Location Last
NTIS  PB89-105399 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
Abstract Sulfolane dosages that alter seizure susceptibility were determined using audiogenic (AG), pentylenetrazol (PTZ) and hippocampal afterdischarge (AD) seizure models. The presence of AG seizures and potentiation of PTZ seizures were investigated in rats injected IP with 0, 200, 400 or 800 mg/kg; AD activity was assessed only at the highest and lowest dosages. The dose-dependent hypothermia associated with sulfolane treatment was controlled in Experiment I and a replication study (Experiment II) by testing under isothermic conditions. The effect of body temperature was measured directly in Experiment III by comparing AG seizure incidence and characteristics exhibited by hypothermic and normothermic animals. Audiogenic seizures were elicited in nearly half of the 800 mg/kg animals in both Experiments I and II. Sulfolane-induced hypothermia, maximal at 3 hours, partially protected against AG seizure characteristics. Potentiation of PTZ seizure severity (800 mg/kg) and duration (800 and 400 mg/kg) also were observed. None of the hippocampal AD parameters was affected significantly by sulfolane treatment. The similarity of the convulsants, sulfolane and PTZ, is discussed. (Copyright (c) Ankho International Inc.)
Supplementary Notes Pub. in Neurobehavioral Toxicity and Teratology, v8 p621-626 1986. Prepared in cooperation with Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Sulfolane Effects on Audiogenic, Pentylenetetrazol and Afterdischarge Seizure Activity.
Category Codes 57Y; 57U; 44G; 68G
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 834421619
Origin NTIS
Type CAT