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Main Title Septotemporal Gradients of Trimethyltin-Induced Hippocampal Lesions.
Author Chang, L. W. ; Dyer, R. S. ;
CORP Author Arkansas Univ. for Medical Sciences, Little Rock.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/161;
Stock Number PB86-100583
Additional Subjects Toxicology ; Rats ; Reprints ; Tin/trimethyl ; Hippocampus
Library Call Number Additional Info Location Last
NTIS  PB86-100583 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Abstract Rats were administered 6 mg/kg trimethyltin (TMT) PO, and sacrificed at various time points (up to 60 days) for pathological evaluation. Studies along the full extent of the septotemporal axia revealed region-specific and cell field-specific damage. Dentate granule cells were most affected at the temporal pole and were only minimally affected at the septal pole. CA3c pyramidal neurons were affected along the full extent of the septotemporal axis. CA3a and CA3b pyramid cells were most affected in the septal pole, and virtually unaffected in the temporal pole. It is suggested that CA3a and CA3b pyramidal cell damage may be dependent upon functionally intact granule cells.
Availability Notes Pub. in Neurobehavioral Toxicology and Teratology 7, n1 p43-49 1985.
NTIS Title Notes Journal article.
Title Annotations Reprint: Septotemporal Gradients of Trimethyltin-Induced Hippocampal Lesions.
PUB Date Free Form c1985
Category Codes 6T; 57Y
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 533917280
Origin NTIS
Type CAT