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Main Title Neurophysiological Consequences of Acute Exposure to Methylpyridines.
Author Dyer, R. S. ; Burdette, L. J. ; Janssen, R. ; Boyes, W. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/265;
Stock Number PB86-158581
Additional Subjects Toxicology ; Bioassay ; Rats ; Laboratory animals ; Dosage ; Reprints ; Pyridines/methyl ; Evoked responses
Library Call Number Additional Info Location Last
NTIS  PB86-158581 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 16p
Abstract A series of neurophysiological tests was performed on Long-Evans hooded rats treated with either 2-, 3- or 4-methylpyridine at dosages of 100mg/kg, approximately 1/2 the i.p. LD50. The tests contained measures of sensory function (paired pluse flash evoked potentials, pattern reversal evoked potentials, brainstem auditory evoked responses) and cerebral excitability (pentylenetetrazol (PTZ) seizures and hippocampal afterdischarges). In general, rats treated with 2- and 3-methylpyridine were more affected than those treated with 4-methylpyridine. The changes observed were in many ways similar to those seen following administration of depressant compounds: increased latency of evoked potentials and increased latency to PTZ seizures. Not all findings, however, were consistent with previously observed patterns of CNS depression.
Supplementary Notes Pub. in Fundamental and Applied Toxicology 5, p920-932 1985. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Neurophysiological Consequences of Acute Exposure to Methylpyridines.
PUB Date Free Form c1985
Category Codes 6T; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 611414530
Origin NTIS
Type CAT