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Main Title Current Research of the Environmental Protection Agency on Automotive Criteria Pollutants.
Author Graham, J. A. ; Horstman, D. H. ; Benignus, V. A. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/D-85/108;
Stock Number PB85-218907
Additional Subjects Environmental surveys ; Exhaust emissions ; Public health ; Exposure ; Ozone ; Nitrogen dioxide ; Carbon monoxide ; Lead(Metal) ; Toxicology ; Laboratory animals ; Respiratory diseases ; Mathematical models ; Extrapolation ; Experimental design ; Asthma ; Neurology ; Air pollution effects(Humans) ; National ambient air quality standards ; Air pollution effects(Animals) ; Automobile exhaust ; Environmental health ; Chemical reaction mechanisms
Library Call Number Additional Info Location Last
NTIS  PB85-218907 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
Abstract The HERL conducts a variety of investigations of the health effects of air pollutants to serve as criteria for the reevaluation of National Ambient Air Quality Standards. Human clinical studies include research on the effects of: (1) ozone (O3) and nitrogen dioxide (NO2) on exercising healthy adults, asthmatics, males vs. females, and blacks vs. whites; (2) O3 and NO2 on pulmonary cell biology and immunology; (3) carbon monoxide (CO) on cardiovascular physiology of patients with ischemic heart disease; and (4) CO on neurophysiology. Human research also includes investigation of the mechanisms of the effects of O3 and NO2 and the relationship between rate of exposure to CO and the level of carboxyhemoglobin formation and effects. The neurophysiological effects of lead are being investigated in humans and monkeys. Animal studies with O3 and NO2 include: (1) evaluation of the progression of chronic lung disease during chronic exposure, (2) determination of the effects on antiviral lung diseases, and (3) investigation of the mechanisms of effects. Quantitative animal-to-man extrapolation models for O3 and NO2 focused on dosimetry and species sensitivity, are under development.
PUB Date Free Form 1985
Category Codes 6E; 6T; 6J; 57U; 68G; 57Y; 68A
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 525518065
Origin NTIS
Type CAT