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Main Title Sulfolane-Induced Hypothermia Enhances Survivability in Mice.
Author Gordon, C. J. ; Long, M. D. ; Fehlner, K. S. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/443;
Stock Number PB88-170931
Additional Subjects Hypothermia ; Survival ; Thermoregulation ; Mice ; Body temperature ; Physiological effects ; Laboratory animals ; Toxicology ; Reprints ; Sulfolane ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB88-170931 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Abstract Mice injected intraperitoneally with sulfolane (tetrahydrothiophene-1, 1-dioxide) undergo a decrease in metabolic rate and body temperature. If given the opportunity, mice treated with sulfolane preferentially seek a cool ambient temperature. At a warm ambient temperature (35 C) neither metabolic rate nor body temperature are decreased by sulfolane. When given the LD50 dose of sulfolane, the percent mortality varies directly with ambient temperature. For example, at 35 C mortality is 75% whereas at 25 C mortality is only 8%. By undergoing an autonomically and behaviorally-mediated decrease in body temperature (i.e., regulated hypothermia), sulfolane-treated mice appear to enhance their chance of survival.
Supplementary Notes Pub. in Environmental Research, v40 p92-97 1986.
NTIS Title Notes Journal article.
Title Annotations Reprint: Sulfolane-Induced Hypothermia Enhances Survivability in Mice.
PUB Date Free Form 1986
Category Codes 68G; 57Z; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 812722666
Origin NTIS
Type CAT