Main Title |
Biochemical and Biological Markers: Implications for Epidemiologic Studies. |
Author |
Griffith, J. ;
Duncan, R. C. ;
Hulka., B. S. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Miami Univ., FL. School of Medicine. ;North Carolina Univ. at Chapel Hill. Dept. of Epidemiology. |
Publisher |
c1989 |
Year Published |
1989 |
Report Number |
EPA/600/J-89/456; |
Stock Number |
PB91-109488 |
Additional Subjects |
Epidemiology ;
Exposure ;
Industrial medicine ;
Toxicity ;
Hazardous materials ;
Research design ;
Biochemical markers ;
Biological markers ;
Toxic substances
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-109488 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Given that a major task for environmental epidemiology is to provide evidence of long-term health risks early enough so that appropriate preventive measures can be taken, biochemical and biological markers of potentially harmful environmental exposures are of great interest and possibly of great value. Such markers are in two discrete classes, those quantitatively related to exposure itself, reflecting the magnitude of such exposures or of the body burden of the pollutants, and those markers which reflect the biological response to such exposures. This paper suggests guidelines for the appropriate use of cross-sectional, retrospective, and prospective designs in epidemiologic investigations of markers of exposure and disease. Also presented are suggestions for the application of sensitivity, specificity, reliability, and acceptability in marker studies since the effectiveness of any marker will ultimately be judged on these characteristics. |
Supplementary Notes |
Pub. in Archives of Environmental Health, v44 n6 p375-381 Dec 89. Prepared in cooperation with Miami Univ., FL. School of Medicine, and North Carolina Univ. at Chapel Hill. Dept. of Epidemiology. |
NTIS Title Notes |
Journal article. |
Category Codes |
57U; 57Y; 68G |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
036519268 |
Origin |
NTIS |
Type |
CAT |