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Main Title Behavioral Toxicity Syndromes: A Promising Tool for Assessing Toxicity Mechanisms in Juvenile Fathead Minnows.
Author Drummond, R. D. A. ; Russom, C. L. ;
CORP Author Environmental Research Lab.-Duluth, MN.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/004;
Stock Number PB90-217688
Additional Subjects Minnows ; Toxicity ; Tables(Data) ; Bioassay ; Reprints ; Environmental monitoring ; Water pollution effects(Animals) ; Startle reaction ; Toxic substances ; Oxidative phosphorylation
Library Call Number Additional Info Location Last
NTIS  PB90-217688 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Abstract Fathead minnows (Pimephales promelas) were exposed to acutely toxic concentrations of organic chemicals under flow-through conditions at 25C for 96 h. Changes in behavior and morphology were systematically recorded to develop a plan for classifying these chemicals. On this basis, three behavioral toxicity syndromes were evident. Each syndrome appears to represent a different general mode of toxic action. The hypoactivity syndrome, reflecting narcosis, is characterized by depressed locomotor activity, loss of startle response and very dark body coloration. The hyperactivity syndrome, representing metabolic dysfunction (e.g., uncouplers of oxidative phosphorylation), is characterized by greatly accelerated locomotor activity, overreaction to stimuli and increased ventilatory activity. The physical deformity syndrome, indicative of neurological dysfunction (e.g., AChE inhibition), is characterized by a high incidence of convulsions, tetany, scoliosis/lordosis and hemorrhage in the vertebral area. The classification approach also should be useful to help delineate specific, underlying mechanisms or sites of chemical action.
Supplementary Notes Pub. in Environmental Toxicology and Chemistry, v9 p37-46 1990.
NTIS Title Notes Journal article.
Title Annotations Reprint: Behavioral Toxicity Syndromes: A Promising Tool for Assessing Toxicity Mechanisms in Juvenile Fathead Minnows.
Category Codes 68D; 57Y
NTIS Prices PC A03/MF A01
Primary Description 600/03
Document Type NT
Cataloging Source NTIS/MT
Control Number 019411361
Origin NTIS
Type CAT