Main Title |
Comparative Mutagenicity of Halogenated Pyridines in the 'Salmonella Typhimurium'/Mammalian Microsome Test. |
Author |
Claxton, L. D. ;
Dearfield, K. L. ;
Spanggord, R. J. ;
Riccio, E. S. ;
Moetelmans, K. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;SRI International, Menlo Park, CA. |
Year Published |
1987 |
Report Number |
EPA/600/J-87/027; |
Stock Number |
PB87-198479 |
Additional Subjects |
Mutagens ;
Salmonella typhimurium ;
Ribosomes ;
Pyridines ;
Hazardous materials ;
Toxicity ;
Chemical tests ;
Halogens ;
Tables(Data) ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB87-198479 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
17p |
Abstract |
The Salmonella/microsome assay with strains TA97, TA98, TA100, and TA102 was used to examine the potential mutagenicity and structure-activity of 16 mono- and dihalogenated pyridines. The chemical reactivity of the halopyridines suggests that nucleophilic displacement of halogens can occur with halogens at positions 2, 4, and 6 being displaced in addition-elimination reactions. 2-Chloropyridine gave a positive result with rat liver metabolic activation, and 2-fluoropyridine gave equivocal results under these conditions. Mutagenic responses were also obtained with 2-chloromethyl pyridine and 3-chloromethyl pyridine, both in the presence and absence of rat liver S-9. These results suggest the halogenated pyridines, especially with halogens at the 2-position, and singly on a methyl substituent, have mutagenic activity in the Salmonella assay. |
Supplementary Notes |
Pub. in Mutation Research 176, p185-198 1987. Prepared in cooperation with SRI International, Menlo Park, CA. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Comparative Mutagenicity of Halogenated Pyridines in the 'Salmonella Typhimurium'/Mammalian Microsome Test. |
PUB Date Free Form |
c1987 |
Category Codes |
68G; 57Y; 57U; 68E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
723226611 |
Origin |
NTIS |
Type |
CAT |