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OLS Field Name OLS Field Data
Main Title Trimethyltin Effects on Auditory Function and Cochlear Morphology.
Author Crofton, K. M. ; Dean, K. F. ; Menache, M. G. ; Janssen., R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;NSI Technology Services Corp., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/236;
Stock Number PB91-117028
Additional Subjects Auditory perception ; Cochlea ; Morphology ; Electrophysiology ; Behavior ; Nervous system ; Rats ; Reprints ; Trimethyltin compounds ; Auditory evoked potentials ; Startle reaction ; Dose-response relationships ; Sensory thresholds
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NTIS  PB91-117028 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/04/1991
Collation 12p
Abstract TMT is a neurotoxicant known to alter auditory function. The study was designed to compare TMT-induced auditory dysfunction using behavioral, electrophysiological, and anatomical techniques. Adult male Long Evans hooded rats (n=9-12/group) were acutely exposed to saline, 3, 5, or 7 mg/kg TMT. Auditory thresholds were determined 11 weeks post-dosing for 5 and 40 kHz tones using reflex modification of the auditory startle response (ASR). Brainstem auditory evoked response (BAER) thresholds were determined for 5, 40, and 80 kHz tonal stimuli 9 weeks post-dosing. Cochlear histology was assessed at 13 weeks post-dosing. Functional endpoints demonstrated a high-frequency hearing loss. ASR thresholds for 40 kHz tones were elevated 25-35 dB in all dosage groups. BAER thresholds for 40 and 80 kHz tones were elevated 30-50 dB in the 5 and 7 mg/kg groups. Organ of Corti surface preparations revealed a pattern of damage suggesting classical ototoxicity. These data demonstrate the utility of the ASR and BAER in detecting functional alterations in audition and indicate that TMT-induced high-frequency hearing loss is associated with cochlear damage. (Copyright (c) 1990 by Academic Press, Inc.)
Supplementary Notes Pub. in Toxicology and Pharmacology, v105 n1 p123-132 Aug 90. Presented at the 1989 Annual Meeting of the Society of Toxicology, Atlanta, Georgia. Prepared in cooperation with NSI Technology Services Corp., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Trimethyltin Effects on Auditory Function and Cochlear Morphology.
Category Codes 57Y; 57S; 57A
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 101123838
Origin NTIS
Type CAT