||7,12-Dimethylbenz(a)anthracene-Induced Modulation of Cytokines Involved in Cytotoxic T Lymphocyte Induction.
House, R. V. ;
Pallardy, M. J. ;
Burleson, G. R. ;
Dean, J. H. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Chemical Industry Inst. of Toxicology, Research Triangle Park, NC. ;Sterling Research Group, Rensselaer, NY. Dept. of Toxicology.
Antigen antibody reactions ;
Cytotoxic T lymphocytes ;
Interferon type I ;
Dose-response relationships ;
Interferon type II ;
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||Murine lymphocytes were exposed to the carcinogenic polycyclic aromatic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA) and several cytokines were measured. Production of interleukin-1 by macrophages, interleukin-2 by EL-4 thymoma, and gamma interferon by activated splenic lymphocytes were not affected by DMBA. However, interleukin-5 (also known as T cell replacing factor) was significantly suppressed by DMBA. Cloned cytotoxic T lymphocyte activity was inhibited in a dose-dependent manner by DMBA and the suppression was significantly enhanced by addition of beta or gamma interferon. The results support the hypothesis that, rather than acting as a non-specific inhibitor of lymphocyte proliferation, DMBA-induced suppression of antigen-specific cytolysis is a mechanism directed against highly-specific cellular targets in the immune process.
||Pub. in In vitro Toxicology, a Jnl. of Molecular and Cellular Toxicology, v2 n4 p267-278 Dec 88. Prepared in cooperation with Chemical Industry Inst. of Toxicology, Research Triangle Park, NC., and Sterling Research Group, Rensselaer, NY. Dept. of Toxicology.
|NTIS Title Notes
||Reprint: 7,12-Dimethylbenz(a)anthracene-Induced Modulation of Cytokines Involved in Cytotoxic T Lymphocyte Induction.
||PC A03/MF A01