| Main Title |
Neurobehavioral Toxicity of Triethyltin in Rats as a Function of Age at Postnatal Exposure. |
| Author |
Ruppert, P. H. ;
Dean, K. F. ;
Reiter, L. W. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1984 |
| Report Number |
EPA/600/J-84/209; |
| Stock Number |
PB85-164812 |
| Additional Subjects |
Toxicology ;
Rats ;
Age(Biology) ;
Exposure ;
Laboratory animals ;
Reprints ;
Tin/triethyl ;
Neurotoxicity
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB85-164812 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
16p |
| Abstract |
Triethyltin (TET) has been shown to be neurotoxic when injected on postnatal day (PND) 5. In the present experiment the authors examined the toxicity of a single exposure to TET at several postnatal ages. Rat pups were injected ip with O(saline), 1.5, 3.0 or 6.0 mg/kg TET bromide on PND 1, 5, 10 or 15. In agreement with the previous data, PND-5 exposure to 6 mg/kg TET produced behavioral toxicity and decreased adult brain weight. High dose pups were less successful in decending on a rope at 20 and 21 days of age, and were hyperactive in figure-eight mazes at 29-30 and 57-58 days of age. The spatial distribution of activity was also altered: photocell counts were increased primarily in the figure-eight area of the maze. The size of the milk bands was reduced in 6 mg/kg pups injected on either PND 1 or PND 5. Preweanling growth was decreased following all injection ages; this reduction was most pronounced for pups exposed to TET on PND 1 and PND 5. Mating behavior was disrupted in 6 mg/kg males irrespective of age at exposure. These data demonstrate a differential sensitivity to the toxicity of TET during postnatal life, with maximal susceptibility on PND 5. |
| Supplementary Notes |
Pub. in NeuroToxicology 5, n4 p9-22 1984. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Neurobehavioral Toxicity of Triethyltin in Rats as a Function of Age at Postnatal Exposure. |
| PUB Date Free Form |
1984 |
| Category Codes |
6T; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
513018477 |
| Origin |
NTIS |
| Type |
CAT |
