| Main Title |
Effects of Diphenylhydatoin and Chloroquine on Monkey Liver Microsomal Mixed-Function Oxidases. |
| Author |
Davis, J. E. ;
Cramer, M. F. ;
Peoples., A. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, N.C. Population Studies Div. ;National Center for Toxicology Research, Jefferson, Ark. ;Miami Univ., Fla. School of Medicine. |
| Year Published |
1977 |
| Report Number |
EPA/600/J-77/093; |
| Stock Number |
PB-278 598 |
| Additional Subjects |
Drugs ;
Oxidoreductases ;
Enzymes ;
Hydantoins ;
Monkeys ;
Bioassay ;
Laboratory animals ;
Ribosomes ;
Liver ;
In vitro analysis ;
Reprints ;
Hydantoin/diphenyl ;
Chloroquine
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-278 598 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
Sixteen adult male squirrel monkeys (Saimiri sciureus) were randomly divided into three treatment groups and one control group. Each treatment group received 10 mg/kg oral doses of diphenylhydantoin and/or chloroquine. Following sacrifice, in vitro assays for activity of liver microsomal mixed-function oxidases were run. The assays confirmed diphenylhydantoin as a potent inducer of mixed-function oxidases. Chloroquine administration had little affect on the enzymes assayed and did not inhibit the diphenylhydantoin induction. (Copyright (c) 1977 by Hemisphere Publishing Corporation.) |
| Supplementary Notes |
Prepared in cooperation with National Center for Toxicology Research, Jefferson, Ark., and Miami Univ., Fla. School of Medicine. |
| Availability Notes |
Pub. in Jnl. of Toxicology and Environmental Health 2, p1193-1199 1977. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effects of Diphenylhydatoin and Chloroquine on Monkey Liver Microsomal Mixed-Function Oxidases. |
| PUB Date Free Form |
16 Feb 77 |
| Category Codes |
6O; 57Q |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323737024 |
| Origin |
NTIS |
| Type |
CAT |
