||Developmental Effects of Methyl Benzimidazolecarbamate Following Exposure during Early Pregnancy.
Cummings, A. M. ;
Ebron-McCoy, M. T. ;
Rogers, J. M. ;
Barbee, B. D. ;
||ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div.
Teratogenic compounds ;
Dose-response relationships ;
Ovum implantation ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Methyl 2-benzimidazolecarbamate (MBC) and its parent compound benomyl are used as agricultural fungicides. Both chemicals are embryotoxic if administered during organogenesis, and benomyl is teratogenic. Rats were administered MBC at 0, 100, 200, 400, or 600 mg/kg/day during Days 1-8 of pregnancy and killed on Day 11 or Day 20 of gestation. On Day 11, embryos were assessed for survival rate, growth parameters, and anomalies. On Day 20, standard developmental toxicity evaluations were performed. Doses of 200 to 600 mg/kg/day MBC reduced embryonic survival by Day 11; exposure to MBC at 100 to 600 mg/kg/day reduced the number of fetuses surviving on Day 20. Evidence of developmental delay was apparent on Day 11 at all doses, and fetal weight was reduced by Day 20.
||Pub. in Fundamental and Applied Toxicology, v18 n2 p288-293 Feb 92. See also PB91-149765. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div.
|NTIS Title Notes
||Reprint: Developmental Effects of Methyl Benzimidazolecarbamate Following Exposure during Early Pregnancy.
||57Y; 57S; 68E
||PC A02/MF A01