| Main Title |
Replacement of Estrogen by Methoxychlor in the Artificially-Induced Decidual Cell Response in the Rat. |
| Author |
Cummings, A. M. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. |
| Publisher |
Feb 93 |
| Year Published |
1993 |
| Report Number |
EPA/600/J-94/390; |
| Stock Number |
PB95-126546 |
| Additional Subjects |
Estrogens ;
Methoxychlor ;
Pesticides ;
Pharmacology ;
Decidua ;
Progesterone ;
Rats ;
Ovariectomy ;
Dose-response relationships ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB95-126546 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
The pesticide methoxychlor (MXC) exhibits estrogenic activity although it is not a steriod. Therefore its mode of action may differ from that of estrogen. Here the author has evaluated the ability of MXC to replace estrogen in the ovariectomized, hormone-treated decidual cell response (DCR) model. Following priming with estrone, ovariectomized rats were treated with estrone plus progesterone, progesterone alone, or progesterone plus various dosage levels of MXC. Within a narrow dose range, MXC can replace estrone and, in combination with progesterone, produce a maximal DCR. In the same manner as that seen with progesterone plus estrone, progesterone plus MXC produced no effect different from progesterone alone at low to intermediate dosages and in inhibition of decidual growth at high doses. The data support the hypothesis that MXC exhibits classical mechanisms of estrongenic activity. |
| Supplementary Notes |
Pub. in Life Sciences, v52 n4 p347-352 Feb 93. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Replacement of Estrogen by Methoxychlor in the Artificially-Induced Decidual Cell Response in the Rat. |
| Category Codes |
68E; 57Q |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
435318906 |
| Origin |
NTIS |
| Type |
CAT |
