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OLS Field Name OLS Field Data
Main Title Distribution of Injury and Microdosimetry of Ozone in the Ventilatory Unit of the Rat.
Author Pinkerton, K. E. ; Mercer, R. R. ; Plopper, C. G. ; Crapo, J. D. ;
CORP Author California Univ., Davis. School of Veterinary Medicine. ;Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher c1992
Year Published 1992
Report Number EPA-R-813113; EPA/600/J-94/050;
Stock Number PB94-137049
Additional Subjects Ozone ; Dosimetry ; Air pollution effects(Animals) ; Toxicity ; Lung ; Bronchi ; Rats ; Scanning electron microscopy ; Pulmonary alveoli ; Reprints ;
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NTIS  PB94-137049 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 05/14/1994
Collation 10p
Abstract The distribution of ozone-induced injury across the ventilatory units of the lungs was determined and compared with the predicted distribution of ozone dose across the same units to evaluate dose-response relationships. Sprague-Dawley rats were exposed to either 0.98 ppm ozone 8 h/day for 90 days or to filtered air only. En bloc microdissection was used to identify and isolate in longitudinal profile the bronchiole-alveolar duct junction, first pair of alveolar duct generations, and intervening bifurcation ridge. Relative ozone dose across the ventilatory unit was estimated using the geometry of the tracheobronchial tree and the volume and surface area distribution within individual ventilatory units. This mathematical model of ozone dose demonstrated a high degree of correlation to the measured tissue injury response. The findings of this study demonstrate that microdosimetry and microtoxicology can be used to determine dose-response relationships within the ventilatory unit and to assess questions of tissue sensitivity in ozone-induced lung injury.
Supplementary Notes Pub. in Jnl. of Applied Physiology, v73 n3 p817-824 Mar 92. Prepared in cooperation with Duke Univ. Medical Center, Durham, NC. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
NTIS Title Notes Journal article.
Title Annotations Reprint: Distribution of Injury and Microdosimetry of Ozone in the Ventilatory Unit of the Rat.
Category Codes 57Y; 68A
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 407719893
Origin NTIS
Type CAT