| Main Title |
Effects of Inhalation of 0.12 and 0.25 Parts per Million Ozone on the Proximal Alveolar Region of Juvenile and Adult Rats. |
| Author |
Barry, B. E. ;
Miller, F. J. ;
Crapo, J. D. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Duke Univ., Durham, NC. |
| Year Published |
1985 |
| Report Number |
EPA/600/J-85/430; |
| Stock Number |
PB86-217874 |
| Additional Subjects |
Ozone ;
Toxicology ;
Bioassay ;
Rats ;
Laboratory animals ;
Exposure ;
Dosage ;
Reprints ;
Air pollution effects(Animals)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-217874 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
One day old or 6 week old male rats were exposed to either 0.25 ppm O3 12 hr/day or to continuous room air for 6 weeks. An additional group of 6 week old rats was exposed to 0.12 ppm of O3 for the same time period. In the animals exposed to 0.25 ppm O3 from 1 day of age (juvenile animals), the number of type I epithelial cells doubled, their mean surface area decreased 38%, and their mean thickness increased 24%. The number of alveolar macrophages doubled. Adult animals exposed to 0.25 and 0.12 ppm O3 showed similar patterns of changes in the epithelium of the proximal alveolar region. Compared to the juvenile animals, the adult 0.25 ppm O3 exposed animals showed more reaction in the interstitium with a doubling of interstitial macrophages, suggesting a mild inflammatory stimulus in the interstitium. Animals exposed to 0.12 ppm O3 showed smaller, but statistically significant changes in the alveolar type I epithelium, suggesting a relatively linear concentration response relationship. These results suggest that low concentrations of O3 cause a chronic epithelial injury in the proximal alveolar region of both juvenile and adult rats and that the extent of these changes occurs in a concentration-dependent manner, even at concentrations at low as 0.12 ppm. |
| Supplementary Notes |
Pub. in Laboratory Investigation, v53 n6 p692-703 Dec 85. Prepared in cooperation with Duke Univ., Durham, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effects of Inhalation of 0.12 and 0.25 Parts per Million Ozone on the Proximal Alveolar Region of Juvenile and Adult Rats. |
| PUB Date Free Form |
c1985 |
| Category Codes |
6T; 57Y; 68A |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
625517091 |
| Origin |
NTIS |
| Type |
CAT |
