| Main Title |
N-Nitrosodiethylamine-Induced Hepatocarcinogenesis in Estuarine Sheepshead Minnow ('Cyprinodon variegatus'): Neoplasms and Related Lesions Compared with Mammalian Lesions. |
| Author |
Couch, J. A. ;
Courtney, L. A. ;
|
| CORP Author |
Environmental Research Lab., Gulf Breeze, FL. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/188; |
| Stock Number |
PB88-161799 |
| Additional Subjects |
Reprints ;
Sheepshead minnows ;
Cyprinodon variegatus ;
DENA ;
Nitrosodiethylamine ;
Hepato carcinogenesis
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-161799 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
27p |
| Abstract |
Groups of estuarine sheepshead minnows (Cyprinodon variegatus) were exposed to 50-60 mg/l N-nitrosodiethylamine (DENA) for five to six weeks. Exposure was stopped and the fish were then transferred to clean, flowing seawater. Induced liver lesions were studied in periodic samples of fish taken during the next 67 weeks of holding. Most of these lesions were compared to their counterpart lesions in the rat. Certain lesions such as hepatocellular carcinomas, cholangiolar carcinomas, spongiosis hepatis (SH), and cholangiofibrosis in the fish have apparent similar cellular origins and morphogenesis to those Lesions in rats, and perhaps in other mammals. SH in the sheepshead minnow apparently arises from perisinusoidal cells and may be a neoplasm of the cell type. The general similarity of response to DENA in sheepshead minnows and rats suggests that the fish has promise as an assay subject for identifying some hepatocarcinogens, and as a sentinel organism for detecting hepatocarcinogens in contaminated coastal waters. |
| Supplementary Notes |
Pub. in Jnl. of the National Cancer Institute, v79 n2 p297-321 Aug 87. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: N-Nitrosodiethylamine-Induced Hepatocarcinogenesis in Estuarine Sheepshead Minnow ('Cyprinodon variegatus'): Neoplasms and Related Lesions Compared with Mammalian Lesions. |
| PUB Date Free Form |
1987 |
| Category Codes |
57Y |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
809821911 |
| Origin |
NTIS |
| Type |
CAT |
