||Will the Mouse Bioassay for Estimating Sensory Irritancy of Airborne Chemicals (ASTM E 981-84) Be Useful for Evaluation of Indoor Air Contaminants.
Tepper, J. S. ;
Costa, D. L. ;
||ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Indoor air pollution ;
Test methods ;
Risk assessment ;
Laboratory tests ;
Air pollution detection ;
Air pollution effects(Humans) ;
American Standard Test Method E 981-84 ;
ASTM E 981-84
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||For many toxic inhalants, sensory irritation is the first detectable response. A standardization bioassay, ASTM E 981-84, that quantitates irritancy as a reduction in breathing rate of the mouse during inhalation exposure, has been developed. The validation of this screen for detecting irritation is based on the high rank-correlation between 0.03 x RD(50) and the TLVs-TWAs for numerous inhaled chemicals. The screen does not indicate the relative offensiveness of an odor, does not address all pulmonary hazards or non-irritating systemic hazards, and is not a replacement for chronic toxicity testing. Despite the limitations, prudent application of ASTM E 981-84 appears to provide a rapid, inexpensive means to identify indoor atmospheres of irritant potential.
||Pub. in Indoor Environment 1, n6 p367-372 Nov 92. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
|NTIS Title Notes
||Reprint: Will the Mouse Bioassay for Estimating Sensory Irritancy of Airborne Chemicals (ASTM E 981-84) Be Useful for Evaluation of Indoor Air Contaminants.
||68A; 68G; 57U
||PC A02/MF A01