| Main Title |
Comparison of In vivo and In vitro Methods for Assessing the Effects of Phenobarbital on the Hepatic Drug-Metabolizing Enzyme System. |
| Author |
Chadwick, R. W. ;
Copeland, M. F. ;
Carlson, G. P. ;
Trela, B. A. ;
Most, B. M. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Purdue Univ., Lafayette, IN. School of Pharmacy and Pharmacal Sciences. ;Northrop Services, Inc., Research Triangle Park, NC. |
| Year Published |
1985 |
| Report Number |
EPA/600/J-85/371; |
| Stock Number |
PB86-187366 |
| Additional Subjects |
Phenobarbital ;
Toxicology ;
Enzymes ;
Comparison ;
Parenteral infusions ;
In viva analysis ;
In vitro analysis ;
Metabolism ;
Rats ;
Dosage ;
Laboratory animals ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-187366 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
The effect of daily i.p. injections of 0, 1, 10 and 80 mg/kg phenobarbital for 1 week on the activity of the hepatic drug-metabolizing enzyme system was measured in the rat by a model substrate assay employing lindane and by a battery of in vitro enzyme assays. Comparison of the dose-response curves of the in vivo and in vitro assays indicated that urinary metabolities of indane provided a good index of phenobarbital-induced change in both phase I and phase II reactions. |
| Supplementary Notes |
Pub. in Toxicology Letters 29, p95-105 1985. Prepared in cooperation with Purdue Univ., Lafayette, IN. School of Pharmacy and Pharmacal Sciences, and Northrop Services, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Comparison of In vivo and In vitro Methods for Assessing the Effects of Phenobarbital on the Hepatic Drug-Metabolizing Enzyme System. |
| PUB Date Free Form |
c1985 |
| Category Codes |
6T; 6E; 57Y; 57O |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
617120211 |
| Origin |
NTIS |
| Type |
CAT |
