Main Title |
Catecholaminergic-Serotonergic Balance in the CNS and Reproductive Cycling in Aging Rats. |
Author |
Cooper, R. L. ;
McNamara, M. C. ;
Linnoila, M. ;
|
CORP Author |
Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1986 |
Report Number |
EPA/600/J-86/004; |
Stock Number |
PB86-176088 |
Additional Subjects |
Central nervous system ;
Reproduction(Biology) ;
Drugs ;
Toxicology ;
Seratonin ;
Rats ;
Laboratory animals ;
Catecholamines ;
Age(Biology) ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB86-176088 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Treatment with the serotonin (5-HT) reuptake inhibitor Zimelidine, 20 mg/kg/24 hrs, s.c., for 14 days increased the duration of vaginal cycles in 3 month-old Long Evans hooded rats. It induced persistent vaginal estrus in 12 or 16 ten-month old animals, and blocked reinitiation of vaginal cycles by L-dopa in 10 of 10 twenty-month old rats. A single injection of zimelidine at 1400 h did not alter the vaginal smear pattern of young or middle-aged cyling females or old constant estrus females. Also, a single dose of zimelidine at 1400 h on the day of vaginal proestrus had no effect on serum LH values in young females. The serotonergic neurotoxin 5,7-hydroxytryptamine, 4 microgram, injected into the ventral and dorsal raphe areas (after desipramine, 25 mg/kg i.p.) reinitiated vaginal cycling in 8 of 13 twenty-month old rats. |
Supplementary Notes |
Pub. in Neurobiology of Aging, v7 n1 p9-15 Jan 86. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
PUB Date Free Form |
c1986 |
Category Codes |
6T; 6O; 57Y; 57Q |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
614222992 |
Origin |
NTIS |
Type |
CAT |