| Main Title |
Interpretation of the Carcinogenicity of Amosite Asbestos and Ferroactinolite on the Basis of Retained Fiber Dose and Characteristics In Vivo. |
| Author |
Cook, Philip M. ;
Palekar, Lalita D. ;
Coffin, David L. ;
|
| CORP Author |
Environmental Research Lab.-Duluth, MN. |
| Year Published |
1982 |
| Report Number |
EPA-600/J-82-243; |
| Stock Number |
PB83-140772 |
| Additional Subjects |
Asbestos ;
Fibers ;
Rats ;
Laboratory animals ;
Malignant neoplasms ;
Reprints ;
Carcinogenesis ;
Ferroactinolite ;
Air pollution effects(Animals) ;
Cancer
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-140772 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Rats were exposed to amosite asbestos and ferroactinolite fibers by intrapleural inoculation and intratracheal instillation. The ferroactinolite sample was found to be more carcinogenic in both exposures than the amosite sample on the basis of total fiber dose or fiber dose expressed for any size category of hypothetical greatest carcinogenic potency. Quantitative transmission electron microscope analysis of low-temperature ashed whole lung samples collected at different times following intratracheal instillation of fibers demonstrated that concentrations and sizes of fibers retained in rat lungs were greatly influenced by the relative ability of each mineral to undergo longitudinal splitting as a consequence of dissolution in vivo. Ferroactinolite fibers rapidly split to produce many thin fibers so that the number of ferroactinolite fibers retained in the lung 2 years after intratracheal instillation was four times greater than the number of fibers originally instilled. The number of short, thin ferroactinolite fibers retained (10-fold more than amosite) after in vivo splitting best explains the greater lung carcinogenicity of ferroactinolite compared to amosite. |
| Supplementary Notes |
Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. Pub. in Toxicology Letters 13, p151-158 1982. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Interpretation of the Carcinogenicity of Amosite Asbestos and Ferroactinolite on the Basis of Retained Fiber Dose and Characteristics In Vivo. |
| PUB Date Free Form |
1982 |
| Category Codes |
6T; 6F; 57Y; 68A |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
309122375 |
| Origin |
NTIS |
| Type |
CAT |
