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Main Title Cytogenetic Analysis of the L5178Y/TK+/- Yields TK-/- Mouse Lymphoma Mutagenesis Assay System.
Author Hozier, J. ; Sawyer, J. ; Moore, M. ; Howard, B. ; Clive, D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Florida Inst. of Tech., Melbourne. ;Burroughs-Wellcome Co., Research Triangle Park , NC.
Year Published 1981
Report Number EPA-600/J-81-048;
Stock Number PB84-101732
Additional Subjects Lymphomas ; Mice ; Laboratory animals ; Assaying ; Reprints ; Cytogenetics ; Mutagenesis
Library Call Number Additional Info Location Last
NTIS  PB84-101732 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
Abstract The L5178Y/TK t/- TK-/- mouse lymphoma mutagen assay, which allows selection of forward mutations at the autosomal thymidine kinase (TK) locus, uses a TK t/- heterozygous cell line, TK t/- 3.7.2C Quantitation of colonies of mutant TK-/- cells in the assay forms the basis for calculations of mutagenic potential of test compounds. The authors have evaluated the banded karyotypes of the parent TK t-/- heterozygous cell line, as well as homozygous TK-/- mutants, in order to relate the genetic and morphological properties of mutant colonies. The parent cell line displays karyotype homogeneity, all cells containing normal mouse chromosomes, readily identifiable chromosome rearrangments, and cell line specific marker chromosomes.
Supplementary Notes Prepared in cooperation with Florida Inst. of Tech., Melbourne and Burroughs-Wellcome Co., Research Triangle Park, NC.
Availability Notes Pub. in Mutation Research 84, p169-181 1981.
NTIS Title Notes Journal article.
Title Annotations Reprint: Cytogenetic Analysis of the L5178Y/TK+/- Yields TK-/- Mouse Lymphoma Mutagenesis Assay System.
PUB Date Free Form c1981
Category Codes 6T; 6C; 57Y; 57F
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 400621582
Origin NTIS
Type CAT