Full Record Display for the EPA National Library Catalog
RECORD NUMBER: 22 OF 24| Main Title | Primer on the Ames 'Salmonella typhimurium' Assay for Mutagenicity. | |||||||||||
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| Author | Claxton, Larry D. ; | |||||||||||
| CORP Author | Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
| Year Published | 1983 | |||||||||||
| Report Number | EPA-600/D-83-058; | |||||||||||
| Stock Number | PB83-219634 | |||||||||||
| Additional Subjects | Salmonella typhimurium ; Deoxyribonucleic acids ; Toxicology ; Bacteria ; Bioassay ; Genes ; Mutations ; Tests ; Ames test ; Mutagenesis ; Genotoxicity | |||||||||||
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| Collation | 19p | |||||||||||
| Abstract | Since interaction with deoxyribonucleic acid (DNA) defines the genotoxic end points detected, simple in vitro tests can be used to monitor or screen most chemicals or mixtures of chemicals for specific genotoxic activity. Bacterial tests to screen classes of chemicals for gene mutations can provide a screen for many potential mutagens, carcinogens, and teratogens. Since the biochemical mechanisms for all mutagens, carcinogens, and teratogens are not the same, however, bacterial tests cannot be expected to detect all genotoxicants. Only by clearly understanding a test's usages and limits, can one most effectively use the information provided by that test. | |||||||||||
| PUB Date Free Form | Jun 83 | |||||||||||
| Category Codes | 6T; 6M; 57Y; 57K | |||||||||||
| NTIS Prices | PC A02/MF A01 | |||||||||||
| Primary Description | 600/11 | |||||||||||
| Document Type | NT | |||||||||||
| Cataloging Source | NTIS/MT | |||||||||||
| Control Number | 321719999 | |||||||||||
| Origin | NTIS | |||||||||||
| Type | CAT |