Main Title |
Effect of Alkoxy Substituents on the Mutagenicity of Some Phenylenediamine-Based Disazo Dyes. |
Author |
Esancy, J. F. ;
Freeman, H. S. ;
Claxton, L. D. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.;North Carolina State Univ. at Raleigh. |
Publisher |
c1990 |
Year Published |
1990 |
Report Number |
EPA/600/J-90/014; |
Stock Number |
PB90-217456 |
Additional Subjects |
Alkoxy compounds ;
Toxicity ;
Azo dyes ;
Reduction(Chemistry) ;
Salmonella typhimurium ;
Tables(Data) ;
Reprints ;
Mutagenicity tests
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-217456 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
18p |
Abstract |
Fifteen aminoazobenzene dyes and seven of their reductive-cleavage products were examined in the Salmonella/microsome assay with strains TA98, TA100, TA1535, TA1537 and TA1538. Dyes tested included five derivatives of 4-aminoazobenzene with different alkoxy substituents (-OCH3, -OCH2CH3, -OCH2CH2CH3, -OCH2CH2CH2CH3 or -OCH2CH2OH) in the 3-position as well as the corresponding derivatives of 4-((4-aminophenyl)azo)N,N-diethylaniline and 4-((4-aminophenyl)azo)N,N-bis(2-hydroxyethyl)aniline. In general, as the size of the substituent ortho to the primary amino group of the dyes was increased, the mutagenicity decreased. A similar trend was observed for the reductive-cleavage products. The results from the latter aspect of the study suggest that the mutagenicity of aminoazobenzene dyes can not be accounted for solely from the properties of their reductive-cleavage products. (Copyright (c) 1990 Elsevier Science Publishers B.V. (Biomedical Division).) |
Supplementary Notes |
Pub. in Mutation Research, v238 p23-38 Jan 90. Sponsored by North Carolina State Univ. at Raleigh. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effect of Alkoxy Substituents on the Mutagenicity of Some Phenylenediamine-Based Disazo Dyes. |
Category Codes |
57Y; 57F |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
019411138 |
Origin |
NTIS |
Type |
CAT |