Main Title |
Mutagenicity of Nitrite-Treated Aqueous Extract of 'Piper betle'; L. |
Author |
Chen, H. C. ;
Chang, Y. S. ;
Lee, T. C. ;
|
CORP Author |
Rhode Island Univ., Kingston. ;National Taiwan Coll. of Marine Science and Technology, Keelung.;Environmental Research Lab., Narragansett, RI. |
Year Published |
1985 |
Report Number |
EPA/600/D-85/126; |
Stock Number |
PB85-220408 |
Additional Subjects |
Asia ;
Nitroso compounds ;
Toxicity ;
Betel quid ;
Carcinomas ;
Chewing ;
Mastication ;
Mutagens ;
Piper betle ;
Salmonella typhimurium ;
Piperidine/N-nitroso ;
Pyrrolidine/N-nitroso ;
Morpholine/N-nitroso ;
Epidemiologic methods
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-220408 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Betel quid is chewed as a masticatory material by people in certain areas of Asia. The quid chewing has been related to oral cancer by epidemiological study. The mutagenic components in the aqueous extracts of betel quid ingredients were studied. Only nitrite-treated aqueous extract of Piper betle L fruits, leaves or rhizoma were demonstrated to exhibit a mutagenic response, using Salmonella typhimurium strains TA100 and TA1535 in the Ames test. When the aqueous extract of the fruit was nitrosated, the greatest number of mutagenic substances were formed at pH 3. The formation of mutagens was enhanced by increasing the temperature from 5 to 95 deg. C. Maximum production of the mutagens occurred within 15 min when nitrosation was conducted at 35 deg. C. The mutagenic components in nitrite-treated aqueous extract of Piper betle L fruit were found to be N-nitrosopiperidine, N-nitrosopyrrolidine, N-nitrosomorpholine, and other compounds, as determined by gas chromatography-thermal energy analyzer. |
Supplementary Notes |
Prepared in cooperation with National Taiwan Coll. of Marine Science and Technology. Keelung. |
Availability Notes |
Pub. in Proceedings of National Science Council (Taiwan), v8 n1 p4-10 Jan 84. |
PUB Date Free Form |
c1985 |
Category Codes |
6C; 6T; 6H; 57C; 57Y; 57L |
NTIS Prices |
Not available NTIS |
Primary Description |
600/05 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
524127285 |
Origin |
NTIS |
Type |
CAT |