| Main Title |
Special report on ingested inorganic arsenic: skin cancer ; nutritional essentiality / |
| Author |
Levine, Tina. ;
Gostomski, Frank. ;
Rispin, A. ;
Scott, C. S. ;
Marcus, W. ;
Chen, C.
|
| Other Authors |
|
| CORP Author |
United States. Environmental Protection Agency. Risk Assessment Forum. |
| Publisher |
U.S. Environmental Protection Agency, |
| Year Published |
1987 |
| Report Number |
EPA/625-3-87-013A |
| Stock Number |
PB88-174503 |
| OCLC Number |
17408723 |
| Subjects |
Skin--Cancer ;
Skin--Cancer--Etiology
|
| Additional Subjects |
Skin--Cancer ;
Skin--Cancer--Etiology ;
Arsenic inorganic compounds ;
Skin cancer ;
Ingestion(Biology) ;
Exposure ;
Metabolism ;
Toxicology ;
Risk ;
Nutrition ;
Medical research ;
Carcinogens
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EHAM |
RA1231.A7S63 1987 |
|
Region 1 Library/Boston,MA |
04/29/2016 |
| EJED |
EPA/625/3-87/013A |
|
OCSPP Chemical Library/Washington,DC |
12/12/2003 |
| ELBD ARCHIVE |
EPA 625-3-87-013A |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
DISPERSAL |
| EMBD |
EPA/625/3-87/013A |
|
NRMRL/GWERD Library/Ada,OK |
02/03/1995 |
| ESAD |
EPA 625-3-87-013A |
|
Region 10 Library/Seattle,WA |
03/23/2010 |
| NTIS |
PB88-174503 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Edition |
SAB review draft. |
| Collation |
1 volume (various pagings) |
| Abstract |
A technical panel of the USEPA's Risk Assessment Forum has studied three special issues regarding certain health effects, particularly skin cancer, associated with arsenic ingestion: (1) the validity of the Taiwan study and its use for dose-response assessment in the U.S. population (2) the interpretation and use of skin lesions reported as arsenic-induced skin cancers, and (3) the role of arsenic as an 'essential' nutritional requirement in the human diet. The Technical Panel also reviewed auxiliary information on genotoxicity, metabolism, and other factors that might suggest the most appropriate approach to dose-response assessment. In brief summary, the analysis shows a causal relationship between ingestion exposure to arsenic and an increased risk of skin cancer. However, there is not sufficient information to evaluate a dose-response according to any specific mechanism that one may postulate. In the absence of fully persuasive evidence for any of the possible mechanisms, a generalized multistate model that is linear at low doses was used to place an upper bound on the expected human cancer dose-response. The report summarizes the Technical Panel's review and analysis of relevant data. |
| Notes |
Includes bibliographical references. Cover title. "Prepared for the Risk Assessment Forum, U.S. Environmental Protection Agency." "November 1987." "EPA/625-3-87-013a." |
| Place Published |
Washington, D.C. |
| Supplementary Notes |
Presented at the Risk Assessment Forum held at Washington, DC., November 1987. |
| Corporate Au Added Ent |
United States. Environmental Protection Agency. Risk Assessment Forum. |
| PUB Date Free Form |
1987 |
| NTIS Prices |
PC A09/MF A01 |
| BIB Level |
m |
| Document Type |
BC |
| Medium |
unmediated |
| Content |
text |
| Carrier |
volume |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20170201054536 |
| Language |
eng |
| Origin |
OCLC |
| Type |
MERGE |
| OCLC Rec Leader |
01929cam 2200517Ka 45010 |
