Main Title |
Health assessment document for 1,2-dichloroethane (ethylene dichloride). |
Author |
Davidson, I. W. F. ;
Parker, J. C. ;
Bosch, S. ;
Gray, D. A. ;
Santodonato, J. ;
Chen, C. W. ;
Miremath, C. B.
|
CORP Author |
United States. Environmental Protection Agency. Environmental Criteria and Assessment Office.; Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office. |
Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, |
Year Published |
1985 |
Report Number |
EPA-600/8-84-006F |
Stock Number |
PB86-122702 |
OCLC Number |
12922195 |
Subjects |
Ethylene dichloride--Toxicology ;
Carcinogens
|
Additional Subjects |
Ethylene dichloride--Toxicology ;
Carcinogens ;
Hazardous materials ;
Industrial hygiene ;
Toxicology ;
Environmental surveys ;
Chlorine organic compounds ;
Assessments ;
Exposure ;
Mutagens ;
Laboratory animals ;
Chemical properties ;
Water pollution ;
Air pollution ;
Chemical analysis ;
Sampling ;
Sources ;
Transport properties ;
Ecology ;
Occupational safety and health ;
Toxic substances ;
Environmental health ;
Ethane/dichloro ;
Pharmacokinetics ;
Path of pollutants ;
Air pollution effects(Animals) ;
Air pollution effects(Humans) ;
Chemical industry ;
Public health ;
Urban areas ;
Industrial wastes ;
Soil analysis ;
Bioassays ;
Chloroethanes ;
Cancer ;
Land pollution
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EHAM |
RA1242.E83 1984 |
|
Region 1 Library/Boston,MA |
04/29/2016 |
EJED |
EPA 600-8-84-006F |
|
OCSPP Chemical Library/Washington,DC |
01/01/1988 |
EKBD |
EPA-600/8-84-006F |
|
Research Triangle Park Library/RTP, NC |
03/19/2004 |
ELBD ARCHIVE |
EPA 600-8-84-006F |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
DISPERSAL |
ERAD |
EPA 600/8-84-006F |
|
Region 9 Library/San Francisco,CA |
02/19/2013 |
ESAD |
EPA 600-8-84-006F |
|
Region 10 Library/Seattle,WA |
03/23/2010 |
NTIS |
PB84-209865 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
NTIS |
PB86-122702 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
1 volume (various pagings) : illustrations ; 28 cm |
Abstract |
Ethylene Dichloride (EDC), a clear, colorless volatile liquid, is principally emitted to the environment during manufacturing. Monitoring data, including ambient urban areas, indicate a concentration of equal to or less than 0.5 ppb for most locations. EDC is rapidly absorbed, metabolized, and eliminated. Unmetabolized EDC is eliminated almost exclusively via the lungs. In humans, the symptoms of acute toxicity from repeated exposures exceeding 60 ppm are irritation of the respiratory tract and eyes and CNS depression. According to available evidence EDC does not adversely affect the reproductive or development process in animals except at maternally toxic levels. Additional human epidemiologic studies are needed to establish conclusively that EDC is not a teratogen and does not cause adverse reproductive effects. Positive responses in different text systems indicate that EDC is a weak, direct-acting mutagen; however, several of its metabolites, formed in animals, are more potent mutagens than EDC. As a carcinogen, EDC induces tumors in rats and mice by various routes of exposure (gavage, intraperitoneally, dermally). However, lifetime inhalation exposure conditions did not produce tumors in rats or mice. Results from animal carcinogen studies, when considered with the positive evidence of mutagenicity and the presence of reactive metabolites and covalent bonding to DNA, suggest that EDC is a potential human carcinogen. |
Notes |
"September 1985." "Final report." "EPA-600/8-84-006F." Includes bibliographical references. |
Place Published |
Research Triangle Park, NC |
Supplementary Notes |
See also PB84-209865. |
Corporate Au Added Ent |
United States. Environmental Protection Agency. Environmental Criteria and Assessment Office. |
PUB Date Free Form |
1985 |
Category Codes |
6E; 6T; 6F; 6J; 68G; 57U; 57H; 57Y |
NTIS Prices |
PC A17/MF A01 |
Primary Description |
600/21 |
BIB Level |
m |
Document Type |
BC |
Medium |
unmediated |
Content |
text |
Carrier |
volume |
Cataloging Source |
OCLC/T |
Control Number |
425825217 |
OCLC Time Stamp |
20160419144101 |
Language |
eng |
Origin |
OCLC |
Type |
MERGE |
OCLC Rec Leader |
01417cam 2200337Ia 45020 |