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Main Title Effects of d-Amphetamine on Behavioral and Autonomic Thermoregulation in Mice (Journal Version).
Author Bushnell, P. J. ; Gordon, C. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1987
Year Published 1987
Report Number EPA/600/J-87/400;
Stock Number PB89-105647
Additional Subjects Dextroamphetamine ; Amphetamines ; Body temperature regulation ; Animal behavior ; Locomotion ; Temperature ; Insisible water loss ; Metabolism ; Mice ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB89-105647 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
Abstract d-Amphetamine has well-known behavioral and sympathomimetic effects in rodents, but its effects on thermoregulation are not well characterized. d-Amphetamine was administered i.p. to mice at doses of 0.1 to 10.0 mg/kg. Locomotor activity and preferred ambient temperature (Ta) were measured for 60 min after injection in a linear temperature gradient, and metabolic rate (MR) and evaporative water loss (EWL) were measured in a metabolic chamber at ambient temperatures of either 20 deg C or 30 deg C. Colonic temperatures (Tc) were obtained 60 min after injection in all cases. Doses of d-amphetamine at 0.3 mg/kg and above reduced preferred Ta from the control value of 30 deg C to about 25 deg C. The behavioral and autonomic heat loss responses induced in mice by d-amphetamine suggest that its thermogenic action is detected by the animal at doses below those producing measurable thermogenesis and that appropriate effectors, from selection of a cool Ta to increasing EWL, are engaged in an orderly progression to maintain normothermia under all but the most challenging conditions.
Supplementary Notes Pub. in Pharmacology Biochemistry and Behavior, v27 p431-435 1987.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effects of d-Amphetamine on Behavioral and Autonomic Thermoregulation in Mice (Journal Version).
Category Codes 57Q; 57S; 57Z
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 833027511
Origin NTIS
Type CAT