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Main Title Modelling Working and Reference Memory in Rats: Effects of Scopolamine on Delayed Matching-to-Position.
Author Bushnell, P. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/350;
Stock Number PB91-163642
Additional Subjects Scopolamine ; Memory ; Pharmacology ; Rats ; Drug dose-response relationship ; Cholinergic receptors ; Reprints ; Delayed matching-to-position ; Spatial discrimination ; Methylscopolamine
Library Call Number Additional Info Location Last
NTIS  PB91-163642 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Abstract A model of working and reference memory in rats is described, based on a discrete-trial operant procedure with concurrent spatial matching and nonspatial discrimination components. Working memory was assessed by delivery of food to rats for pressing one of two retractable levers after a delay if that lever had been presented in the prior sample phase of the trial. Reference memory was assessed on other trials by delivering food by pressing the lever illuminated by a cue light after the delay interval. The model was tested with scopolamine (0.10 to 0.56 mg/kg, ip), which reduced matching accuracy in a dose-related manner. Linear slope and intercept estimates of retention gradients showed that intercepts declined and slopes remained unchanged with increasing scopolamine dose, suggesting that cholinergic blockade disrupts encoding processes while sparing retention. In contrast, scopolamine had no effect on nonspatial discrimination accuracy, suggesting insensitivity of reference memory to cholinergic blockade. To compare the effects of scopolamine on spatial and nonspatial discriminations, a second group of rats was trained to discriminate between the spatial locations of two levers.
Supplementary Notes Pub. in Behavioural Pharmacology, v1 p419-427 Nov 90.
NTIS Title Notes Journal article.
Title Annotations Reprint: Modelling Working and Reference Memory in Rats: Effects of Scopolamine on Delayed Matching-to-Position.
Category Codes 57S; 57T; 57Q
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 113027466
Origin NTIS
Type CAT