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Main Title Effect of Chlorine Dioxide and Its Metabolites in Drinking Water on Fetal Development in Rats.
Author Suh, D. H. ; Abdel-Rahman, M. S. ; Bull, R. J. ;
CORP Author New Jersey Medical School, Newark. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-R-807473; EPA-600/J-83-052;
Stock Number PB84-138627
Additional Subjects Chlorine dioxide ; Toxicology ; Potable water ; Rats ; Embryos ; Reprints ; Metabolites ; Drinking water ; Water pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB84-138627 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Abstract The chlorination of surface waters is known to form trihalomethanes. Therefore, chlorine dioxide (CIO2) is being considered as an alternative disinfectant. This study was designed to determine the effect of chlorine dioxide and its metabolites, chlorite (CIO2) and chlorate (CIO3), on rat fetuses exposed in utero. Female rats were administed CIO2 at 0,1,10 and 100 mg1-1 and or CIO3 at 1 and 10 mg 1-1 daily in the drinking water for 2 1/2 months prior to and throughout gestation. Rats were killed on day 20 and fetuses examined for external, skeletal and visceral malformations. Slight decreases in weight gain during pregnancy were seen in the CIO2 administered groups. A significant dose-response relationship in the decreases of the numbers off implants and live fetuses were observed in the CIO2 groups.
Availability Notes Pub. in Jnl. of Applied Toxicology, v3 n2 p75-79 1983.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effect of Chlorine Dioxide and Its Metabolites in Drinking Water on Fetal Development in Rats.
PUB Date Free Form c1983
Category Codes 6T; 6F; 57Y; 68D
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 407621168
Origin NTIS
Type CAT