Main Title |
Method for Combining and Comparing Short-Term Genotoxicity Test Data: Preface. A Report from ICPEMC Committee 1. |
Author |
Brusick, D. J. ;
Ashby, J. ;
de Serres, F. J. ;
Lohman, P. H. M. ;
Matsushima, T. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Leiden Rijksuniversiteit (Netherlands). ;Lawrence Livermore National Lab., CA. ;Hazleton Labs. America, Inc., Vienna, VA.;Department of Energy, Washington, DC. |
Publisher |
c1992 |
Year Published |
1992 |
Report Number |
EPA/600/J-93/399; |
Stock Number |
PB93-236362 |
Additional Subjects |
Mutagenicity tests ;
Mutagens ;
Comparison ;
Chromosome aberrations ;
Neoplastic cell transformation ;
Drosophila ;
DNA repair ;
Dose-response relationships ;
Statistical analysis ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-236362 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
63p |
Abstract |
Short-term testing methods, encompassing a wide variety of species and genetic mechanisms, have been developed to detect genetic effects produced by chemicals. The use of multiplicity of tests has created a difficult and controversial challenge in the interpretation of mixed test results. The driving principle of this report and the International Commission for Protection against Environmental Mutagens and Carcinogens (ICPEMC) Committee 1 was to combine the major parameters of testing (dose, metabolic activation, sign of response, and the replication of test data) into a single score which could be pooled by entry, by test (e.g., Salmonella reverse mutation), by test class (e.g., bacterial mutation), and by family (in vitro or in vivo), into a composite score for a chemical. The system is designed: (i) to cope with redundant data, disagreement, and sporadically filled matrices; (ii) to supply statistical properties by chemical and by test; and (iii) to have features of self-learning to improve predictive performance and internal consistency for any one of several types of genetic hazard. |
Supplementary Notes |
Pub. in Mutation Research, v266 n1 p7-25 Mar 92. See also PB89-109680. Prepared in cooperation with Leiden Rijksuniversiteit (Netherlands), Lawrence Livermore National Lab., CA., and Hazleton Labs. America, Inc., Vienna, VA. Sponsored by Department of Energy, Washington, DC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Method for Combining and Comparing Short-Term Genotoxicity Test Data: Preface. A Report from ICPEMC Committee 1. |
Category Codes |
57Y; 57F |
NTIS Prices |
PC A04/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
330925753 |
Origin |
NTIS |
Type |
CAT |