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OLS Field Name OLS Field Data
Main Title Exposure Related Dose Estimating Model (ERDEM): A Physiologically-Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Model for Assessing Human Exposure and Risk.
Author Blancato, J. N. ; Power, F. W. ; Brown, R. N. ; Dary, C. C. ;
CORP Author Environmental Protection Agency, Research Triangle Park, NC. National Exposure Research Lab.
Publisher Jun 2006
Year Published 2006
Report Number EPA/600/R-06/061; NERL-RTP-HEASD-06-084;
Stock Number PB2006-114712
Additional Subjects Human exposure ; Risk assessment ; Chemicals ; Toxicology ; Absorption ; Circulation ; Enzymes ; Metabolism ; Computer software ; Exposure Related Dose Estimating Model(ERDEM) ; PBPK/PD(Physiologically-Based Pharmacokinetic and Pharmacodynamic)
Library Call Number Additional Info Location Last
NTIS  PB2006-114712 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 05/28/2007
Collation 162p
Abstract Over recent years, physiologically based pharmacokinetic (PBPK) models have been used to better describe internal doses resulting from exposures to chemicals in the environment. PBPK models are mathematical descriptions of how chemicals are absorbed into, transported through, eliminated from, and stored in the body. More recently, physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) models are being used to mathematically describe not only the disposition of a chemical in the body, but also how some normal biologic processes are altered as a result of the chemical in the body. PBPK/PD models should provide the ability to evaluate, estimate, and predict measures of toxicologically relevant doses. The Exposure Related Dose Estimating Model (ERDEM) is a PBPK/PD modeling system that was developed by EPA's National Exposure Research Laboratory (NERL). The ERDEM framework provides the flexibility either to use existing models and to build new PBPK and PBPK/PD models to address specific science questions. Over the past several years, ERDEM has been enhanced to improve ease of operation and to provide additional modeling capabilities. With these enhancements, ERDEM has been applied to a variety of chemicals as part of the regulatory risk assessment process. Applications for malathion and N- methyl carbamate were presented to and peer-reviewed by the FIFRA Scientific Advisory Panel. This report provides information on the use of ERDEM and related software.
Supplementary Notes Microfiche reproduction is in black and white.
Availability Notes Also available on CD-ROM. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
Category Codes 57; 62B
NTIS Prices PC A09/MF A02
Primary Description 600/08
Document Type NT
Cataloging Source NTIS/MT
Control Number 029001360
Origin NTIS
Type CAT