| Main Title |
Mutagenicity and Clastogenicity of Proflavin in L5178Y/TK(+/-)-3.7.2.C Cells. |
| Author |
DeMarini, D. M. ;
Brock, K. H. ;
Doerr, C. L. ;
Moore, M. M. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. |
| Year Published |
1988 |
| Report Number |
EPA/600/J-88/017; |
| Stock Number |
PB88-219779 |
| Additional Subjects |
Mutations ;
Genetic ;
Chromosome abnormalities ;
Reprints ;
Mutagenicity ;
Clastogenicity ;
Proflavin ;
Genetic mutations ;
Biological effects
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-219779 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
The paper evaluated the ability of proflavin to induce specific-locus mutations at the heterozygous thymidine kinase (tk) locus of L5178Y/TK+/- -3.7.2.C mouse lymphoma cells, which permit the recovery and classification of mutants due to single-gene or chromosomal mutation. Proflavin was highly mutagenic at the tk locus, producing 724-965 TK mutants/10(6); survivors. The potent clastogenicity of proflavin was confirmed by cytogenetic analysis for chromosomal aberrations. These results lead to the conclusion that proflavin induces few single-gene mutations in mammalian cells; instead, it is a potent clastogen and produces primarily chromosomal mutations. The authors discuss the possible involvement of DNA topoisomerase II in the clastogenic mechanism of proflavin. |
| Supplementary Notes |
Pub. in Mutation Research, v204 p323-328 1988. Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Mutagenicity and Clastogenicity of Proflavin in L5178Y/TK(+/-)-3.7.2C Cells. |
| PUB Date Free Form |
c1988 |
| Category Codes |
57F |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
826014814 |
| Origin |
NTIS |
| Type |
CAT |
