Main Title |
Effects of Inhaled Hexachlorobenzene Aerosols on Rat Pulmonary Host Defenses. |
Author |
Sherwood, R. L. ;
Thomas, P. T. ;
O'Shea, W. J. ;
Bradof, J. N. ;
Ratajczak, H. V. ;
|
CORP Author |
IIT Research Inst., Chicago, IL. Life Sciences Dept.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1989 |
Year Published |
1989 |
Report Number |
EPA/600/J-89/238; |
Stock Number |
PB90-143058 |
Additional Subjects |
Lung ;
Toxicology ;
Aerosols ;
Chlorobenzenes ;
Respiration ;
Mice ;
Rats ;
Lymph nodes ;
Reprints ;
T lymphocytes ;
B lymphocytes ;
Macrophages ;
Mitogens ;
Phagocytosis
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-143058 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
13p |
Abstract |
Pulmonary bactericidal activity, macrophage phagocytic activity, alveolar macrophage (AM) enzyme activity and T- and B-cell mitogenesis of lymphocytes from lung associated (LALN) or mesenteric lymph nodes (MESLN) were assessed in rats and/or mice exposed 4 hr/d, 4 days/wk for 1, 4 or 16 days to hexachlorobenzene (HCB) aerosols. Pulmonary bactericidal activity was depressed in rats following 1 or 4 but not 16 exposures to 35 mg/cu m HCB. Single 4-hr exposures of 25-45 mg/cu m HCB did not alter bactericidal activity in mice. Rat AM phagocytosis of (51)Cr-RBC in vitro was increased after 4 but not 1 or 16 exposures to HCB while no effect was observed in peritoneal macrophages. HCB significantly enhanced B-cell mitogenesis in MESLN following 4 exposures while LALN B-cell mitogenesis and LALN and MESLN T-cell mitogenesis were not affected. However, after 16 exposures the T-cell responses in LALN and MESLN were significantly increased and decreased, respectively. The studies show that inhalation of 35 mg/cu m HCB alters immunologic and pulmonary defenses of the rat. (Copyright (c) 1989 Princeton Scientific Publishing Co., Inc.) |
Supplementary Notes |
Pub. in Toxicology and Industrial Health, v5 n3 p451-461 1989. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effects of Inhaled Hexachlorobenzene Aerosols on Rat Pulmonary Host Defenses. |
Category Codes |
57Y; 57J |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
007529579 |
Origin |
NTIS |
Type |
CAT |