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OLS Field Name OLS Field Data
Main Title Alpha(2)-Adrenergic Mode of Action of Chlordimeform on Rat Visual Function.
Author Boyes, W. K. ; Moser, V. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
Year Published 1988
Report Number EPA/600/J-88/039;
Stock Number PB88-225768
Additional Subjects Insecticides ; Acaricides ; Adrenergics ; Visual perception ; Central nervous system ; Laboratory animals ; Chlorine organic compounds ; Amidines ; Reprints ; Chlordimeform ; Adrenergic alpha receptors ; Toxic substances ; Visual evoked potentials ; CAS 6164-98-3 ; Formamidine/chloro-tolyl-dimethyl
Library Call Number Additional Info Location Last
NTIS  PB88-225768 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 12/29/1988
Collation 17p
Abstract The hypothesis that chlordimeform increased the amplitude of components N;P1 and P1N3 in rat pattern-reversal visual evoked potentials through actions on alpha2 adrenergic receptors was tested. Yohimbine alone had no effect on pattern-reversal evoked potential amplitude. Clonidine treatment produced a dosage related increase in amplitude of both components similar to that produced by chloroimeform. Yohimbine pretreatment attenuated the effects of subsequent treatment with either clonidine or chlordimeform. The results support the hypothesis that chlordimeform alters rat pattern-reversal evoked potentials through actions as a central nervous system alpha2 adrenergic agonist. (Copyright (c) Academic Press, Inc.)
Supplementary Notes Pub. in Toxicology and Applied Pharmacology, v92 p402-418 1988. Prepared in cooperation with Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Alpha(2)-Adrenergic Mode of Action of Chlordimeform on Rat Visual Function.
PUB Date Free Form c1988
Category Codes 57Y; 57I; 68E
NTIS Prices PC A03/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 826018589
Origin NTIS
Type CAT