||Neurophysiological Effects of 30 Day Chronic Exposure to Toluene in Rats.
Dyer, R. S. ;
Muller, K. E. ;
Janssen, R. J. ;
Barton, C. N. ;
Boyes, W. K. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Northrop Services, Inc., Research Triangle Park, NC.
Neurophysiological effects ;
Laboratory animals ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Long-Evans hooded rats were exposed to 1000 ppm toluene or 0 ppm toluene 6 hr/day, 5 days/week for 30 days. Following removal from the exposure conditions (18-26 hr) flash-evoked potentials were recorded to paired light flashes and pentylenetetrazol (PTZ) seizure properties were examined. No alterations were found in the response to the first flash, but alterations in the recoverability of the nervous system were demonstrated by significant latency shifts in the response to the second of the paired flashes, using first flash latencies as covariates. No significant alterations were found in PTZ seizures. The data indicated that at these exposure levels toluene produced a small but significant alteration in brain function, even after toluene had been completely metabolized.
||Prepared in cooperation with North Carolina Univ. at Chapel Hill, and Northrop Services, Inc., Research Triangle Park, NC.
||Pub. in Neurobehavioral Toxicology and Teratology, v6 n5 p363-368 Sep 84.
|NTIS Title Notes
||Reprint: Neurophysiological Effects of 30 Day Chronic Exposure to Toluene in Rats.
|PUB Date Free Form
||Not available NTIS