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OLS Field Name OLS Field Data
Main Title Monoamine Oxidase Inhibition Cannot Account for Changes in Visual Evoked Potentials Produced by Chlordimeform.
Author Boyes, W. K. ; Moser, V. C. ; MacPhail, R. C. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/240;
Stock Number PB86-137049
Additional Subjects Toxicology ; Insecticides ; Inhibitors ; Insecticides ; Chlorine organic compounds ; Rats ; Laboratory animals ; Reprints ; Chlordimeform ; Evoked responses ; Formamidine/N-(chloro-tolyl)-n-n-dimethyl
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NTIS  PB86-137049 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 10p
Abstract Chlordimeform (CDM), a formamidine insecticide and monoamine oxidase (MAO) inhibitor, has recently been shown to produce profound changes in visual evoked potentials of hooded rats (Dyer and Boyes, The Toxicologist, 3: 13, 1983). Two experiments were performed to determine if the evoked potential changes were a result of MAO inhibition. In the first, the degree of MAO inhibition in the brains of rats treated with CDM (1.0 to 100 mg/kg i.p.) was compared with that produced by MAO inhibitor pargyline (0.3 to 30 mg/kg i.p.). Both compounds preferentially inhibited MAO-B, although MAO-A was substantially inhibited at higher dosages. Pargyline was a relatively more potent MAO inhibitor than CDM, but not more efficacious. In the second study, pattern reversal evoked potentials (PREPs) and flash evoked potentials (FEPs) were recorded from groups of rats after treatment with either saline, 0.4 mg/kg pargyline, 20 mg/kg pargyline, or 40 mg/kg CDM.
Supplementary Notes Pub. in Neuropharmacology, v24 n9 p853-860 1985.
NTIS Title Notes Journal article.
Title Annotations Reprint: Monoamine Oxidase Inhibition Cannot Account for Changes in Visual Evoked Potentials Produced by Chlordimeform.
PUB Date Free Form 1985
Category Codes 6T; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 605827052
Origin NTIS
Type CAT