Main Title |
Neurophysiological Consequences of Acute Exposure to Methylpyridines. |
Author |
Dyer, R. S. ;
Burdette, L. J. ;
Janssen, R. ;
Boyes, W. K. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. |
Year Published |
1985 |
Report Number |
EPA/600/J-85/265; |
Stock Number |
PB86-158581 |
Additional Subjects |
Toxicology ;
Bioassay ;
Rats ;
Laboratory animals ;
Dosage ;
Reprints ;
Pyridines/methyl ;
Evoked responses
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB86-158581 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
16p |
Abstract |
A series of neurophysiological tests was performed on Long-Evans hooded rats treated with either 2-, 3- or 4-methylpyridine at dosages of 100mg/kg, approximately 1/2 the i.p. LD50. The tests contained measures of sensory function (paired pluse flash evoked potentials, pattern reversal evoked potentials, brainstem auditory evoked responses) and cerebral excitability (pentylenetetrazol (PTZ) seizures and hippocampal afterdischarges). In general, rats treated with 2- and 3-methylpyridine were more affected than those treated with 4-methylpyridine. The changes observed were in many ways similar to those seen following administration of depressant compounds: increased latency of evoked potentials and increased latency to PTZ seizures. Not all findings, however, were consistent with previously observed patterns of CNS depression. |
Supplementary Notes |
Pub. in Fundamental and Applied Toxicology 5, p920-932 1985. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Neurophysiological Consequences of Acute Exposure to Methylpyridines. |
PUB Date Free Form |
c1985 |
Category Codes |
6T; 57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
611414530 |
Origin |
NTIS |
Type |
CAT |