| Main Title |
Chlordimeform Produces Profound, Selective, and Transient Changes in Visual Evoked Potentials of Hooded Rats. |
| Author |
Boyes, W. K. ;
Dyer, R. S. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1984 |
| Report Number |
EPA/600/J-84/258; |
| Stock Number |
PB85-192961 |
| Additional Subjects |
Toxicity ;
Pesticides ;
Insecticides ;
Acaricides ;
Chlorine organic compounds ;
Visual perception ;
Rats ;
Laboratory animals ;
Formamidines ;
Chlordimeform ;
Dose rate ;
Electric stimulation
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB85-192961 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17p |
| Abstract |
Rat visual function was tested after acute exposure to chlordimeform (CDM), a formamidine insecticide/acaricide. Adult male Long-Evans rats were surgically implanted with epidural recording electrodes overlying visual cortex and tested 1 week later. Pattern reversal-evoked potentials (PREPs), flash-evoked potentials (FEPs), and FEP recovery ratios were measured after acute CDM administration. In the first study, which examined dose-response relationships, i.p. injections of 0 (saline), 5, 15, or 40 mg/kg CDM-HCl were administered 30 min prior to testing. In the second study, which examined the time course of CDM action, PREPs and paired-pulse FEPs were recorded 3, 6, and 24 h after dosage with either 0 or 40 mg/kg CDM. In summary, acute exposure to CDM temporarily increased both the amplitude and latency of PREPs, but only the latency of FEPs. |
| Supplementary Notes |
Pub. in Experimental Neurology 86, p434-447 1984. |
| NTIS Title Notes |
Journal article. |
| PUB Date Free Form |
1984 |
| Category Codes |
6T; 6F; 6C; 57Y; 57Z; 68E |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
518921034 |
| Origin |
NTIS |
| Type |
CAT |
