| Main Title |
Trimethyltin Reduces Recurrent Inhibition in Rats. |
| Author |
Dyer, R. S. ;
Boyes, W. K. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1984 |
| Report Number |
EPA/600/J-84/257; |
| Stock Number |
PB85-192946 |
| Additional Subjects |
Toxicity ;
Inhibition ;
Rats ;
Trimethyltin compounds ;
Neurotoxins ;
Electric stimulation ;
Recurrence
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB85-192946 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
5p |
| Abstract |
Rats with electrodes chronically implanted in the perforant path for electrical stimulation, and dentate gyrus for recording were treated with a single oral administration of either saline, 5 mg/kg trimethyltin (TMT) or 6 mg/kg TMT. Recurrent inhibition was assessed by paired pulse activation of the perforant path input to the dentate gyrus. The measure of recurrent inhibition employed was the ratio of the population spike amplitudes of the responses to the first and second of the paired stimuli. Inhibition was assessed immediately before, and at 2, 24 and 120 hrs following TMT. The results indicated a reduction in inhibition as early as 2 hr following treatment, suggesting that TMT-induced destruction of hippocampal pyramidal cells may be secondary to their over-activation from an uninhibited mossy fiber system. |
| Supplementary Notes |
Pub. in Neurobehavioral Toxicology and Teratology 6, n5 p369-371 Sep 84. |
| NTIS Title Notes |
Journal article. |
| PUB Date Free Form |
1984 |
| Category Codes |
6T; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
518921025 |
| Origin |
NTIS |
| Type |
CAT |
