| Main Title |
Rat and Human Visual-Evoked Potentials Recorded Under Comparable Conditions: A Preliminary Analysis to Address the Issue of Predicting Human Neurotoxic Effects from Rat Data. |
| Author |
Hudnell, H. K. ;
Boyes, W. K. ;
Otto., D. A. ;
|
| CORP Author |
Environmental Protection Agency, Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/158; |
| Stock Number |
PB91-116095 |
| Additional Subjects |
Toxicology ;
Nervous system ;
Rats ;
Human ;
Patterns ;
Spatial distribution ;
Reprints ;
Visual evoked potentials ;
Species specificity ;
Predictive value of tests
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-116095 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
A search was undertaken for contributions of sustained and transient visual elements to the rat visual-evoked potential (VEP) using procedures similar to those used in humans. Evoked potentials were recorded following either pattern-reversal or pattern-onset stimulation over a range of spatial frequencies, and following adaptation to a stationary grating of the same spatial frequency as the test stimulus. The initial VEP component, a positive peak labeled P1, was early in latency, larger at lower spatial frequencies, larger following pattern-reversal than pattern-onset stimulation, and not reduced in amplitude by adaptation to a stationary grating. These properties suggest that P1 reflects the activity of a transient, motion-perception visual subsystem. Subsequent in latency to P1 was a negative peak labeled N2 which was largest at intermediate spatial frequencies, larger following pattern-onset than pattern-reversal stimulation, and reduced in amplitude by adaptation to a stationary grating. These properties suggest that N2 reflects the activity of a pattern-perception visual subsystem. |
| Supplementary Notes |
Pub. in Neurotoxicology and Teratology, v12 n4 p391-398 Aug 90. Prepared in cooperation with North Carolina Univ. at Chapel Hill. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Rat and Human Visual-Evoked Potentials Recorded Under Comparable Conditions: A Preliminary Analysis to Address the Issue of Predicting Human Neurotoxic Effects from Rat Data. |
| Category Codes |
57Y; 57S |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
200/04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
101123400 |
| Origin |
NTIS |
| Type |
CAT |
