| Main Title |
Formation of DNA Adducts in 1OT1/2 Mouse Embryo Fibroblasts Incubated with Benzo(a)pyrene or Dihydrodiol Oxide Derivatives. |
| Author |
Brown, Halina Szejnwald ;
Jeffrey, Alan M. ;
Weinstein, I. Bernard ;
|
| CORP Author |
Columbia Univ., New York.;Health Effects Research Lab., Research Triangle Park, NC.;National Cancer Inst., Bethesda, MD. |
| Year Published |
1979 |
| Report Number |
EPA-R-805482 ;PHS-CA-13696; EPA-600/J-79-148; |
| Stock Number |
PB83-145292 |
| Additional Subjects |
Deoxyribonucleic acid ;
Aromatic polycyclic hydrocarbons ;
Binding ;
Mice ;
Embryos ;
Oxygen organic compounds ;
Stereochemistry ;
Reprints ;
Dihydrodiol oxide ;
Metabolites ;
Cell lines ;
Benzopyrenes ;
Fibroblasts
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-145292 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Binding of benzo(a)pyrene (BP) metabolites to DNA was studied in the mouse embryo fibroblast 10T one half cell line. The cells metabolized BP to its diastereoisomeric 7,8-dihydrodiol-9,10-oxides, (+)-7B, 8a-dihydroxy-9B, 10B-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene, which formed covalent adducts with cellular DNA. Detailed analysis by high-pressure liquid chromatography indicated that a deoxyguanosine adduct, N2-(10S-(7R, 8S, 9R-trihydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene)yldeoxyguaninosine, was the predominant DNA adduct formed in cells exposed to BP. This adduct is also the major one found in human tissues exposed to BP. |
| Supplementary Notes |
Pub. in Cancer Research 39, p1673-1677 May 79. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Formation of DNA Adducts in 1OT1/2 Mouse Embryo Fibroblasts Incubated with Benzo(a)pyrene or Dihydrodiol Oxide Derivatives. |
| PUB Date Free Form |
30 Jan 79 |
| Category Codes |
6A; 57B |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
305048128 |
| Origin |
NTIS |
| Type |
CAT |
