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Main Title Evidence for Direct Effect of Magnetic Fields on Neurite Outgrowth.
Author Blackman, C. F. ; Benane, S. G. ; House, D. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher Jun 93
Year Published 1993
Report Number EPA/600/J-93/413;
Stock Number PB93-236669
Additional Subjects Neurites ; Magnetic fields ; In vitro analysis ; In vivo analysis ; Electric fields ; Nerve growth factors ; Growth ; PC12 cells ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-236669 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Abstract Electric fields can cause changes in cell responses both in vitro and in vivo. Alternating magnetic fields have been proposed to act through the electric fields induced in the conducting medium surrounding the cells. The authors have used a simple exposure system to test the relative contribution of magnetic fields compared to induced electric fields in a standard PC-12 cell culture assay, in which cells respond to nerve growth factor by producing neurites. This response to stimulation by nerve growth factor is inhibited by sinusoidal, 50-Hz magnetic fields at field strengths below 10 microT (100 mG). A standard procedure to distinguish magnetic- versus electric-field effects demonstrates that the induced electric field is not involved. Additional work is necessary to identify the critical reaction site(s), and to establish the molecular mechanisms responsible for these results.
Supplementary Notes Pub. in FASEB Jnl., v7 n9 p801-806 Jun 93. See also PB86-175403.
NTIS Title Notes Journal article.
Title Annotations Reprint: Evidence for Direct Effect of Magnetic Fields on Neurite Outgrowth.
Category Codes 57V; 57F
NTIS Prices PC A02/MF A01
Document Type NT
Cataloging Source NTIS/MT
Control Number 330926057
Origin NTIS
Type CAT