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Main Title Role of Sample Temperature in the Field-Induced Alteration of Calcium Release from Brain Tissue, In vitro.
Author Blackman, C. F. ; Benane, S. G. ; House, D. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1989
Year Published 1989
Report Number EPA/600/D-89/211;
Stock Number PB90-130949
Additional Subjects Calcium ; Brain ; Radiofrequency heating ; Electromagnetic fields ; In vitro analysis ; Exposure ; Chickens ; Brain chemistry
Library Call Number Additional Info Location Last
NTIS  PB90-130949 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Abstract The release of calcium ions from in vitro preparations of chicken brain-tissue has been used by several investigators to demonstrate the interaction of electric and magnetic (EM) fields with biological systems. For exposures with radiofrequency radiation amplitude modulated at extremely low frequencies (ELF), the observations have all been of field-induced enhancement of the calcium release. In contrast, when only ELF EM fields are employed, the release of calcium ions has been reported by one research group to be inhibited and by another group, enhanced. The results in the report demonstrate that either observation, or a null result, is possible under exposure to 16-Hz sinusoidal EM fields, at 14.1 Vrms/m (in air), and 64 nTesla-rms, depending upon the thermal condition of the samples prior to and during exposure. When the sample temperature is ascending during the 20 minute exposure enhanced release is observed, when stable during exposure (i.e., within + or - 0.3C of the final temperature) the release is reduced, and when descending a null result occurs. This finding may reconcile the disagreement in the direction of the field-induced response and explain the reason the experimental result is so difficult to replicate.
Category Codes 57B; 57V
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 004016656
Origin NTIS
Type CAT