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RECORD NUMBER: 17 OF 17

Main Title

Updated mutagenicity and carcinogenicity assessment of cadmium /

Author

Anderson, L. D. ; Bayard, S. ; Bayliss, D. L. ; Beliles, R. P. ; Tanchel, N. A.

CORP Author

United States. Environmental Protection Agency. Office of Health and Environmental Assessment.; Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.

Publisher

U.S. Environmental Protection Agency, Office of Research and Development,

Year Published

1984

Report Number

EPA-600/ 8-83-025b

Stock Number

PB85-116150

OCLC Number

10713531

Subjects

Cadmium--Toxicology ; Carcinogens ; Environmental health

Additional Subjects

Cadmium--Toxicoloy ; Carcinogens ; Environmental health ; Toxicology ; Mutagens ; Assessments ; Epidemiology ; Laboratory animals ; Air pollution ; Industrial hygiene ; Exposure ; Cadmium chloride ; Malignant neoplasms ; Public health ; Risk ; Toxic substances ; Cadmium compounds ; Occupational safety and health ; Air pollution effects(Humans) ; Air pollution effects(Animals)

Internet Access

Description	Access URL
	https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=30001BAQ.PDF

Holdings

Library	Call Number	Additional Info	Location	Last Modified
EHAM	RA1231 .C3U6 1984		Region 1 Library/Boston,MA	04/29/2016
EKBD	EPA-600/8-83-025B		Research Triangle Park Library/RTP, NC	03/19/2004
ELBD RPS	EPA 600-8-83-025B	repository copy	AWBERC Library/Cincinnati,OH	03/26/2019
ESAD	EPA 600-8-83-025b		Region 10 Library/Seattle,WA	09/06/2005
NTIS	PB85-116150	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Edition

External review draft.

Collation

viii, 174 pages : illustrations ; 28 cm

Abstract

This draft document evaluates the mutagenicity and carcinogenicity of cadmium, supplementing an earlier document (Health Assessment Document for Cadmium, May 1981) which dealt with all health effects. Since the earlier document was prepared, a rat inhalation carcinogenicity study has been reported and several epidemiology and mutagenicity papers have been published. This draft document tentatively concludes that: (1) there is evidence suggesting that cadmium and certain cadmium compounds are weakly mutagenic; (2) cadmium chloride aerosol induces lung cancer in rats; (3) injected cadmium salts induce injection site sarcomas and testicular tumors in both mice and rats; (4) there is limited epidemiologic evidence that inhaled cadmium induces prostate and/or lung cancer in highly exposed workers; (5) there is no evidence that cadmium is carcinogenic via ingestion, which is a major route of human exposure, and the upper limit of potency via ingestion is at least 200 times less than via inhalation.

Notes

"Do not quote or cite." "EPA-600/ 8-83-025b." "April 1984." "Addendum to the Health Assessment Document for Cadmium (May 1981)--EPA-600/ 8-91-023."

Place Published

Washington, D.C.

Supplementary Notes