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Main Title Carcinoma of the Exocrine Pancreas in Medaka.
Author Fournie, J. W. ; Hawkins, W. E. ; Battalora, M. S. J. ; Walker., W. W. ;
CORP Author Environmental Research Lab., Gulf Breeze, FL. ;Gulf Coast Research Lab., Ocean Springs, MS.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/341;
Stock Number PB92-129782
Additional Subjects Water pollution effects(Animals) ; Carcinogens ; Oryzias ; Pancreatic neoplasms ; Benzopyrenes ; Methylazoxymethanol acetate ; Carcinogenicity tests ; Histology ; Peritoneal neoplasms ; Reprints ; Dimethylbenzanthracenes
Library Call Number Additional Info Location Last
NTIS  PB92-129782 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Abstract Eight cases of acinar cell carcinoma of the exocrine pancreas were diagnosed in Japanese medaka (Oryzias latipes) from a pool of approximately 10,000 specimens used in a variety of carcinogenesis bioassays. Three cases occurred in specimens from control groups and one case in a specimen exposed to benzo(e)pyrene (BeP), a noncarcinogenic isomer of benzo(a)pyrene (BaP). Four cases occurred in specimens exposed to known carcinogens including two cases in specimens exposed to 7,12-dimethylbenz(a)anthracene (DMBA), one in a medaka exposed to benzo(a)pyrene, and one in a specimen exposed to methylazoxymethanol acetate (MAM-Ac). Pancreatic carcinoma was probably the cause of death in five cases. The neoplasms appeared to originate in the mesentery near the abdominal surface of the liver.
Supplementary Notes Pub. in Jnl. of Aquatic Animal Health, v3 p213-220 1991. See also PB88-196266. Prepared in cooperation with Gulf Coast Research Lab., Ocean Springs, MS.
NTIS Title Notes Journal article.
Title Annotations Reprint: Carcinoma of the Exocrine Pancreas in Medaka.
Category Codes 68D; 57Y; 57E
NTIS Prices PC A02/MF A01
Primary Description 600/04
Document Type NT
Cataloging Source NTIS/MT
Control Number 205224023
Origin NTIS
Type CAT