Main Title |
Teratology of a zineb fo[r]mulation / |
Other Authors |
|
Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory, |
Year Published |
1980 |
Report Number |
EPA-600/1-80-017; EPA-68-02-2982 |
Stock Number |
PB80-181175 |
OCLC Number |
47899442 |
Subjects |
Fungicides--Research ;
Fungicides--Toxicology
|
Additional Subjects |
Toxicology ;
Fungicides ;
Congenital abnormalities ;
Rats ;
Mice ;
Laboratory animals ;
Ingestion(Biology) ;
Dosage ;
Pregnancy ;
Toxic substances ;
Teratogenesis ;
Zineb ;
Ethylenebis(dithiocarbamates) zinc
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EHBD |
EPA-600/1-80-017 |
|
CEMM/ACESD Library/Narragansett,RI |
03/16/2007 |
EJBD |
EPA 600-1-80-017 |
|
Headquarters Library/Washington,DC |
04/24/2014 |
EKBD |
EPA-600/1-80-017 |
|
Research Triangle Park Library/RTP, NC |
09/07/2001 |
ELBD ARCHIVE |
EPA 600-1-80-017 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
NTIS |
PB80-181175 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
vi, 19 p. ; 28 cm. |
Abstract |
The purpose of the present study was to evaluate the teratogenic potential of a zineb formulation. An initial toxicity study indicated that oral doses of 1,000 or 2,000 mg/kg/day adversely affected the weight gain of nonpregnant rats but not nonpregnant mice. In the teratology study pregnant rats and mice received daily oral doses of 0, 200, 632, or 2,000 mg/kg from day 6 of gestation until the day before C-section. Maternal welfare, as monitored by body weight and food consumption, was affected only in rats that received 2,000 mg/kg/day of the formulation. Evidence of embryo or fetal lethality was not present in rats or mice. However, fetuses from rats that received 2,000 mg/kg/day of the formulation had a reduced body weight. Some anomalies were significantly increased in rats that received 2,000 mg/kg/day of the formulation. These anomalies included hydrocephalus, split centra, incompletely ossified frontal bones, and enlarged occipital fontanel. None of the anomalies observed in mice were increased to a statistically significant level in any of the groups treated with the formulation. This study indicated that the zineb formulation produced anomalies in rats at doses which adversely affected maternal welfare. In addition, there was no evidence of teratogenicity in mice treated with similar doses. |
Notes |
EPA Project Officer: Ronald L. Baron. Prepared by Midwest Research Institute for U.S. Environmental Protection Agency. "February 1980." Includes bibliographical references (p. 18). "EPA-600/1-80-017." |
Place Published |
Research Triangle Park, N.C. |
Access Notes |
Also available via the World Wide Web. |
Corporate Au Added Ent |
Health Effects Research Laboratory (Research Triangle Park, N.C.); United States. Environmental Protection Agency. Office of Research and Development.; Midwest Research Institute (Kansas City, Mo.) |
Title Ser Add Ent |
Research reporting series. Environmental health effects research. |
Alternate Title |
Teratology of Zineb Formulation |
PUB Date Free Form |
1980 |
Series Title Traced |
Research reporting series Environmental health effects research |
Series Title Untraced |
Research reporting series. 1, Environmental health effects research |
NTIS Prices |
PC A03/MF A01 |
BIB Level |
m |
Cataloging Source |
OCLC/T |
OCLC Time Stamp |
20130717122834 |
Language |
eng |
Origin |
OCLC |
Type |
MERGE |
OCLC Rec Leader |
01607cam 2200373Ka 45020 |